TocilizumabV1, Main, Exploration, bibRecord, 000C77

Fatal myocarditis and rhabdomyositis in a patient with stage IV melanoma treated with combined ipilimumab and nivolumab

Identifieur interne : 000C77 ( Main/Exploration ); précédent : 000C76; suivant : 000C78

Fatal myocarditis and rhabdomyositis in a patient with stage IV melanoma treated with combined ipilimumab and nivolumab

Auteurs : S. D. Saibil [Canada] ; L. Bonilla [Canada] ; H. Majeed [Canada] ; V. Sotov [Canada] ; D. Hogg [Canada] ; M. A. Chappell [Canada] ; M. Cybulsky [Canada] ; M. O. Butler [Canada]

Source :

Current Oncology [ 1198-0052 ] ; 2019.

RBID : PMC:6588051

Abstract

Combination immune checkpoint blockade with concurrent administration of the anti-ctla4 antibody ipilimumab and the anti–PD-1 antibody nivolumab has demonstrated impressive responses in patients with advanced melanoma and other diseases. That combination has also been associated with increased toxicity, including rare immune-related adverse events. Here we describe a case of fatal steroid-refractory myocarditis and panmyositis associated with the use of this combination in a patient with metastatic melanoma. Correlative studies indicated increased levels of serum interleukin 6 in this patient at the onset of toxicity, suggesting a possible role for anti–interleukin 6 receptor antibodies in the treatment of subsequent cases of this rare, but fatal, toxicity.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588051

DOI: 10.3747/co.26.4381
PubMed: 31285688
PubMed Central: 6588051

Affiliations:

Le document en format XML

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Fatal myocarditis and rhabdomyositis in a patient with stage IV melanoma treated with combined ipilimumab and nivolumab

Fatal myocarditis and rhabdomyositis in a patient with stage IV melanoma treated with combined ipilimumab and nivolumab

Source :

Abstract

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